Dr. Leng's research focuses on stroke and intracranial atherosclerotic disease (ICAD). In the past few years, Dr. Leng has been utilizing multimodal neuroimaging and computational methods to study cerebral hemodynamics and plaque characteristics in ICAD and its clinical implications, using a cross-disciplinary approach. She also works on the efficacy and safety of medical and interventional treatment regimens in ischemic stroke, and investigates mechanisms of collateral circulation recruitment and its prognostic values in stroke patients. In these research areas, she has close collaboration with University of Oxford, University of California Los Angeles, Shenzhen Institutes of Advanced Technology of the Chinese Academy of Sciences, and Beijing Tiantan Hospital of Capital Medical University.

Dr. Leng has been funded by the Research Grants Council of Hong Kong, Health and Medical Research Fund, the National Natural Science Foundation of China, China Association for Science and Technology, and the Lee Hysan Foundation. Since 2013, Dr. Leng has published more than 110 peer-reviewed articles in international academic journals, including Circulation, Ann Neurol, Neurology, J Neurol Neurosurg Psychiatry, Stroke, etc.

-Imaging, treatment and prognosis of ischemic stroke and intracranial atherosclerotic disease
-Cerebral hemodynamics and plaque characteristics in intracranial atherosclerotic disease
-Collateral circulation in ischemic stroke and intracranial atherosclerotic disease